Evaluation of the PEN-FAST clinical decision rule in non–beta-lactam antibiotic allergy assessment
Despite lower NPV for non-beta-lactam labels and varying performance across antibiotic classes, our results indicate that PEN-FAST may serve as a safe risk stratification tool for non-beta-lactam allergy labels. Prospective studies with direct drug challenges are required to assess its utility in the delabeling of non-beta-lactam allergies.
Authors
- Elham Khatamzas
- Alexander Enk (ORCID: https://orcid.org/0000-0002-7358-185X)
- Knut Schäkel (ORCID: https://orcid.org/0000-0001-6344-7799)
- Deniz Göcebe
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- German Center for Infection Research (DE)
Publication Details
- Journal
- Annals of Allergy Asthma & Immunology
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1016/j.anai.2025.06.019
- Citations
- 2
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Deutsche Forschungsgemeinschaft