AIM2 activation mediated by RIPK1/3-dependent mitochondrial DNA release drives Aβ1−40-Induced retinal pigment epithelium injury
Our study is the first to validate AIM2's contribution in Aβ-induced RPE pathology and underscore the significance of the RIPK1/RIPK3-induced mtDNA release in modulating inflammatory responses, shedding light on the underlying mechanisms and potential therapeutics of AMD.
Authors
- Tongqi Li
- Xiaodong Sun (ORCID: https://orcid.org/0000-0001-7775-2823)
- Shiqi Yang (ORCID: https://orcid.org/0000-0002-3076-0567)
- Xiaoling Wan (ORCID: https://orcid.org/0000-0003-4583-8686)
- Tong Li (ORCID: https://orcid.org/0000-0002-2544-1254)
- Bo Yu (ORCID: https://orcid.org/0000-0001-8964-7617)
- Xinyue Zhu (ORCID: https://orcid.org/0000-0003-4900-1621)
- Xiaoxu Huang (ORCID: https://orcid.org/0000-0002-2631-5284)
- Xiaohuan Zhao (ORCID: https://orcid.org/0000-0001-9109-7909)
- Junran Sun (ORCID: https://orcid.org/0000-0001-6545-5223)
- Jieqiong Chen (ORCID: https://orcid.org/0000-0003-1673-6517)
- Guanran Zhang (ORCID: https://orcid.org/0000-0002-6818-0648)
- Qiyu Bo
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Stomatological Hospital (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Shanghai First People's Hospital (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1186/s12964-025-02294-w
- Citations
- 6
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Shanghai Municipal Education Commission
- National Key Research and Development Program of China