Harnessing Radicals for the Selenotrifluoromethylation within a Confined Metal–Organic Framework
Herein, we report a UiO-67-type metal-organic framework as an efficient photocatalyst for the selenyltrifluoromethylation of terminal alkynes. The CF<sub>3</sub>• radical species can be effectively stabilized within the confined space of UiO-67-Ru, which contributes to the superior <i>regio</i>-selectivity and catalytic activity. Furthermore, the <i>stereo</i>-selectivity of the obtained (<i>E</i>)-α,β-unsaturated selenotrifluoromethyl compounds is well elucidated by means of density functional theory (DFT) calculations and canonical Monte Carlo (CMC) simulation.
Authors
- Jiewei Liu (ORCID: https://orcid.org/0000-0001-9688-7133)
- Cong Zhao (ORCID: https://orcid.org/0000-0001-7186-0567)
- Yan‐Zhong Fan
- Yajun Zhao (ORCID: https://orcid.org/0000-0001-6551-5863)
- Lu Chen (ORCID: https://orcid.org/0000-0002-9601-4241)
- Ya Li (ORCID: https://orcid.org/0000-0002-4677-1236)
- Jiabin Chen (ORCID: https://orcid.org/0009-0004-4526-8534)
- Guangqing Wang (ORCID: https://orcid.org/0000-0003-4342-9360)
- X. LAN
Institutions
- Society of Automotive Engineers International (US)
- South China University of Technology (CN)
- Wuyi University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1021/acs.orglett.5c01983
- Citations
- 2
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.58
Funders
- National Natural Science Foundation of China
- Department of Education of Guangdong Province