Uterine Spindle Cell Sarcoma Presenting With Lower Gastrointestinal Bleeding: A Case Report

This case report presents a rare clinical manifestation of uterine spindle cell sarcoma, an aggressive and uncommon malignancy, in a 79-year-old female patient. The patient presented with lower gastrointestinal (GI) bleeding, constipation, and significant weight loss. Colonoscopy identified an infiltrative, ulcerated mass within the sigmoid colon, later confirmed by biopsy as a high-grade spindle cell sarcoma of uterine origin. Given the unresectable status of the mass, chemotherapy was initiated as the primary treatment. This report discusses the diagnostic challenges and highlights the importance of considering atypical presentations in patients with lower GI bleeding and weight loss.

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Publication Details

Journal
Cureus
Published
2025-06-21
DOI
https://doi.org/10.7759/cureus.86486
Primary Topic
Uterine Myomas and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Uterine Spindle Cell Sarcoma Presenting With Lower Gastrointestinal Bleeding: A Case Report

Shatha Elemian, Ahmad Radaideh, Byron Okwesili, Andre Fedida et al.
Cureus
Uterine Myomas and Treatments
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Uterine Spindle Cell Sarcoma Presenting With Lower Gastrointestinal Bleeding: A Case Report

Shatha Elemian, Ahmad Radaideh, Byron Okwesili, Andre Fedida, Ismail Althunibat, LAITH SOROUR, Ahmad Habbas
article en

Abstract

This case report presents a rare clinical manifestation of uterine spindle cell sarcoma, an aggressive and uncommon malignancy, in a 79-year-old female patient. The patient presented with lower gastrointestinal (GI) bleeding, constipation, and significant weight loss. Colonoscopy identified an infiltrative, ulcerated mass within the sigmoid colon, later confirmed by biopsy as a high-grade spindle cell sarcoma of uterine origin. Given the unresectable status of the mass, chemotherapy was initiated as the primary treatment. This report discusses the diagnostic challenges and highlights the importance of considering atypical presentations in patients with lower GI bleeding and weight loss.

CureusVol. 17(6)
Saint Francis Hospital (US), St. Francis Hospital (US), Saint Michael's Medical Center (US)
Zero hunger
Openalex Percentile: Top 81%
Uterine Myomas and Treatments
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