HBx mutant-regulated RPL13AP25 mediates suboptimal virological response to entecavir and HCC progression
The HBx-H94Y/K130M mutant, selected during the period of suboptimal virological response, appears to promote cccDNA accumulation, likely through the upregulation of RPL13AP25, which contributed to HCC progression.
Authors
- Po‐Heng Chuang (ORCID: https://orcid.org/0000-0003-3711-5445)
- Chau‐Ting Yeh (ORCID: https://orcid.org/0000-0001-7376-275X)
- Rong‐Nan Chien (ORCID: https://orcid.org/0000-0001-7656-4695)
- Kwang‐Huei Lin (ORCID: https://orcid.org/0000-0002-5649-2222)
- Yang-Hsiang Lin (ORCID: https://orcid.org/0000-0003-4295-6062)
- Yu‐De Chu (ORCID: https://orcid.org/0000-0002-5496-8573)
- Chih‐Lang Lin (ORCID: https://orcid.org/0000-0002-1225-3895)
- Chao‐Wei Hsu
- M. W. Lai
Institutions
- Chang Gung University of Science and Technology (TW)
- Chang Gung University (TW)
- Jen-Ai Hospital (TW)
- Chang Gung Memorial Hospital (TW)
- Keelung Chang Gung Memorial Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
- Central Taiwan University of Science and Technology (TW)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1186/s12935-025-03873-0
- Citations
- 1
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Chang Gung Medical Foundation
- Chang Gung Memorial Hospital, Linkou
- National Science and Technology Council