Comprehensive analysis of single-cell and bulk RNA sequencing data unveils antigen-presenting and processing fibroblasts and establishes a predictive model in gastric cancer
APPFs may play an important role in the regulation of tumor immune microenvironment in GC and warrant further exploration. The predictive model based on APPFRGs effectively predicts the prognosis and tumor immune status of GC.
Authors
- Chenggang Zhang (ORCID: https://orcid.org/0000-0002-4521-3304)
- Guanmo Liu
- Juan Sun
- Weiming Kang (ORCID: https://orcid.org/0000-0002-6736-4728)
- Xin Ye (ORCID: https://orcid.org/0000-0001-8355-4516)
- Jie Li (ORCID: https://orcid.org/0000-0001-7516-2774)
- Yihua Wang (ORCID: https://orcid.org/0000-0001-5561-0648)
- Fangqi Chen (ORCID: https://orcid.org/0000-0003-1108-7343)
- Zicheng Zheng
- Yixuan He (ORCID: https://orcid.org/0009-0002-2681-7919)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Chinese Academy of Medical Sciences Dermatology Hospital (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1186/s12935-025-03878-9
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bethune Charitable Foundation