Decoding the impact of exercise and αCGRP signaling on murine post-traumatic osteoarthritis progression
This study highlights αCGRP as an intrinsic regulator of joint and bone responses to mechanical loading during OA. While cartilage degradation after DMM and treadmill exercise was unaffected by lack of αCGRP, its deficiency altered ECM stiffness, bone remodeling, and inflammatory responses. These findings position αCGRP as a critical regulator of joint homeostasis, particularly for bone health during running exercise and OA progression.
Authors
- Nicole Schäfer (ORCID: https://orcid.org/0000-0002-3897-624X)
- Arndt F. Schilling (ORCID: https://orcid.org/0000-0001-7022-1069)
- Verena Maier
- Hauke Clausen‐Schaumann (ORCID: https://orcid.org/0000-0002-9413-0310)
- Susanne Grässel
- Patrick Pann
- Paul Kalke
Institutions
- Universitätsmedizin Göttingen (DE)
- University of Regensburg (DE)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1186/s13075-025-03589-6
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Universität Regensburg