Independent histological validation of MR-derived radio-pathomic maps of tumor cell density using image-guided biopsies in human brain tumors
MRI-derived machine learning generated cellularity prediction maps (CPM) enabled a non-invasive evaluation of tumor cellularity in treatment-naïve glioma patients, although CPM did not clearly outperform ADC alone in this cohort.
Authors
- Noriko Salamon (ORCID: https://orcid.org/0000-0002-3520-9467)
- Richard G. Everson (ORCID: https://orcid.org/0000-0003-2809-3061)
- Benjamin M. Ellingson (ORCID: https://orcid.org/0000-0002-2764-6640)
- Jingwen Yao (ORCID: https://orcid.org/0000-0002-8828-1841)
- Peter S. LaViolette (ORCID: https://orcid.org/0000-0002-9602-6891)
- Gianluca Nocera (ORCID: https://orcid.org/0000-0002-8499-5257)
- Francesco Sanvito (ORCID: https://orcid.org/0000-0003-3379-9958)
- Antonella Castellano (ORCID: https://orcid.org/0000-0002-4137-9016)
- Timothy F. Cloughesy (ORCID: https://orcid.org/0000-0002-8656-7483)
- Pietro Mortini (ORCID: https://orcid.org/0000-0003-2320-2281)
- Sonoko Oshima (ORCID: https://orcid.org/0000-0002-1453-3807)
- Samuel Bobholz (ORCID: https://orcid.org/0000-0003-1525-7418)
- Linda M. Liau (ORCID: https://orcid.org/0000-0002-4053-0052)
- Catalina Raymond (ORCID: https://orcid.org/0000-0003-2757-439X)
- Kunal Patel (ORCID: https://orcid.org/0000-0002-9854-9178)
- Jennifer Connelly (ORCID: https://orcid.org/0000-0002-6122-8573)
- Ashley Teraishi (ORCID: https://orcid.org/0009-0004-3442-8109)
Institutions
- Vita-Salute San Raffaele University (IT)
- University of California, Los Angeles (US)
- Medical College of Wisconsin (US)
- Kyoto University (JP)
- Ronald Reagan UCLA Medical Center (US)
- IRCCS Ospedale San Raffaele (IT)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1007/s11060-025-05105-x
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- U.S. Department of Defense
- American Brain Tumor Association
- National Brain Tumor Society
- Sontag Foundation
- National Institutes of Health
- National Cancer Institute
- Congressionally Directed Medical Research Programs