Five-year safety and growth response of long-acting PEGylated recombinant human growth hormone in children with growth hormone deficiency—data from CGLS database
• Data from the CGLS database confirms that PEG-rhGh has an acceptable safety profile over five years, with significant improvement in height. Importantly, the data indicate that initiating the treatment earlier yields better outcomes.
Authors
- Hongxiao Zhang (ORCID: https://orcid.org/0000-0002-0721-367X)
- Wei Gu (ORCID: https://orcid.org/0000-0002-2480-6645)
- Feihong Luo (ORCID: https://orcid.org/0000-0002-6433-7994)
- Xiaoping Luo (ORCID: https://orcid.org/0000-0002-3748-4817)
- Yaping Ma (ORCID: https://orcid.org/0000-0002-6710-5259)
- Xiaoyan Huang (ORCID: https://orcid.org/0000-0002-1169-9887)
- Naijun Wan (ORCID: https://orcid.org/0000-0001-5411-5397)
- Hongwei Du (ORCID: https://orcid.org/0000-0002-9744-098X)
- Guimei Li (ORCID: https://orcid.org/0000-0002-1784-4555)
- Chunxiu Gong (ORCID: https://orcid.org/0000-0002-1262-7383)
- Kundi Wang
- Yun-Pu Cui (ORCID: https://orcid.org/0000-0002-4357-2717)
- Lirong Ying
- Jingsi Luo (ORCID: https://orcid.org/0000-0003-2289-7309)
- Xu Xu (ORCID: https://orcid.org/0000-0002-8958-5302)
- Nan Li (ORCID: https://orcid.org/0000-0002-2584-0634)
- Haiying Wu (ORCID: https://orcid.org/0009-0009-5083-2722)
- Zheng Liu (ORCID: https://orcid.org/0000-0002-0405-2348)
- Zhihong Chen (ORCID: https://orcid.org/0000-0002-9545-1327)
- Yuwen Li (ORCID: https://orcid.org/0000-0002-6218-148X)
- Chunlin Wang (ORCID: https://orcid.org/0000-0002-3411-0617)
- Yuan Li (ORCID: https://orcid.org/0000-0002-4552-5180)
- Huiwen Zhang (ORCID: https://orcid.org/0000-0002-8241-325X)
- Liyan Ma
- Haiyan Wei (ORCID: https://orcid.org/0000-0003-1044-6594)
- Yufang Zhao (ORCID: https://orcid.org/0000-0001-6092-4625)
- Rongxiu Zheng (ORCID: https://orcid.org/0000-0001-6118-0218)
- Min Zhu (ORCID: https://orcid.org/0000-0002-4800-4161)
- Liyang Liang (ORCID: https://orcid.org/0000-0002-4112-3520)
- Ruimin Chen (ORCID: https://orcid.org/0000-0003-4114-7706)
- Jin Cai
- Yan Zhong (ORCID: https://orcid.org/0000-0003-1132-5567)
- Kan Ye
- Wei Wu (ORCID: https://orcid.org/0000-0003-4228-2416)
- Yuqing Chen (ORCID: https://orcid.org/0000-0002-9188-7406)
- Tingting Wang (ORCID: https://orcid.org/0000-0002-6440-4827)
Institutions
- Qingdao University (CN)
- Jiangnan University (CN)
- Shandong University (CN)
- Sun Yat-sen University (CN)
- Capital Medical University (CN)
- Jilin University (CN)
- Nantong University (CN)
- Peking University (CN)
- China-Japan Friendship Hospital (CN)
- XinHua Hospital (CN)
- Tianjin Medical University General Hospital (CN)
- Beijing Jishuitan Hospital (CN)
- Affiliated Hospital of Nantong University (CN)
- First People's Hospital of Yunnan Province (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Changchun Institute of Biological Products (CN)
- Wuxi Fourth People's Hospital (CN)
- Suzhou Municipal Hospital (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Jinhua Academy of Agricultural Sciences (CN)
- Lanzhou University Second Hospital (CN)
- First Hospital of Jilin University (CN)
- Ningxia Medical University (CN)
- Hunan Children's Hospital (CN)
- Ningxia Medical University General Hospital (CN)
- Peking University Third Hospital (CN)
- Beijing Children’s Hospital (CN)
- Jiangsu Province Hospital (CN)
- Children's Hospital of Fudan University (CN)
- Tongji Hospital (CN)
- Jinhua Central Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Huazhong University of Science and Technology (CN)
- Lanzhou University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- European Journal of Pediatrics
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1007/s00431-025-06268-5
- Citations
- 2
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Huazhong University of Science and Technology
- Tongji University
- National Key Research and Development Program of China
- Tongji Medical College, Huazhong University of Science and Technology