Uncovering encrypted antimicrobial peptides in health-associated Lactobacillaceae by large-scale genomics and machine learning
We uncovered the global prevalence of AMPs in Lactobacillaceae and proved that Lactobacillaceae is an untapped and invaluable source of novel AMPs to combat the antibiotic-resistance crisis. Meanwhile, we provided a machine learning-guided framework for AMP discovery, offering a scalable roadmap for identifying novel AMPs not only in Lactobacillaceae but also in other organisms. Video Abstract.
Authors
- Qun Wu (ORCID: https://orcid.org/0000-0002-3266-7040)
- Yongguang Huang (ORCID: https://orcid.org/0000-0001-7393-5630)
- Zhen Li (ORCID: https://orcid.org/0000-0003-1177-2818)
- Fei Han (ORCID: https://orcid.org/0000-0002-9707-4713)
- Yan Xu
- Rubing Du
- Jing Yu (ORCID: https://orcid.org/0000-0003-0327-9601)
Institutions
- Jiangnan University (CN)
- Nanjing Normal University (CN)
- Guizhou University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1186/s40168-025-02145-3
- Citations
- 3
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions