In-vitro transcriptomic profiling of indigenous Gaddi vis-à-vis exotic Labrador dogs: insights from systems biology
The study highlights distinct immunological profiles between Labrador and Gaddi dogs, with no shared genes responding to TLR-ligand stimulation. The functional enrichment of miRNA targets demonstrated consistent regulatory patterns at both the mRNA and miRNA levels. These findings emphasize the importance of preserving the genetic diversity of indigenous Gaddi dogs and utilizing advanced sequencing techniques to explore immunological diversity for disease resistance and the selection of breeding individuals.
Authors
- Bilawal Singh
- Jaswinder Kaur (ORCID: https://orcid.org/0000-0002-0567-9468)
- R. S. Sethi (ORCID: https://orcid.org/0000-0003-0416-8946)
- Mani Mohan
- Chandra Sekhar Mukhopadhyay (ORCID: https://orcid.org/0000-0002-4545-4204)
- Deepti Narang (ORCID: https://orcid.org/0000-0002-8960-6388)
- Simarjeet Kaur (ORCID: https://orcid.org/0000-0003-2963-3621)
Institutions
- Guru Angad Dev Veterinary and Animal Sciences University (IN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-06-20
- DOI
- https://doi.org/10.3389/fvets.2025.1489905
- Citations
- 1
- Primary Topic
- Human-Animal Interaction Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- Guru Angad Dev Veterinary and Animal Sciences University