Prognostic implications of high- OXPHOS macrophages in gastric cancer: a single-cell transcriptomics and tumor microenvironment communication study
The high-OXPHOS-macrophage-related prognostic signature derived from scRNA-seq data provides valuable insights into GC patient stratification. NPC2, LY96, and TPP1, highly expressed in TAMs, were implicated in promoting tumor growth and immune escape, offering potential targets for novel therapeutic interventions.
Authors
- Lin Cheng (ORCID: https://orcid.org/0000-0002-6031-3899)
- Ziyuan Lin (ORCID: https://orcid.org/0009-0003-4650-495X)
- Xiaohe Xu (ORCID: https://orcid.org/0000-0001-8761-0511)
- Qifeng Zhao (ORCID: https://orcid.org/0000-0003-0902-3199)
- Yunyu Xu
- Xihuang Lin (ORCID: https://orcid.org/0000-0001-7250-0539)
Institutions
- Bengbu Medical College (CN)
- Henan University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-06-20
- DOI
- https://doi.org/10.3389/fonc.2025.1533990
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00