Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis
The persistent presence of CD206, CD68<sup>+</sup>Arginase-1<sup>+</sup> and CD68<sup>+</sup>PD-L1<sup>+</sup> cells within the inflamed, parasitized splenic tissue, alongside a relative decline in CD68<sup>+</sup>NOS2<sup>+</sup> cells, may create a permissive environment for parasite survival and replication, thereby sustaining the inflammatory response. This chronic exposure to antigenic and inflammatory stimuli likely contributes to persistent tissue damage, exemplified by splenic white pulp disorganization in the spleen, and exacerbates disease progression.
Authors
- F. N. Ribeiro (ORCID: https://orcid.org/0000-0002-1379-5549)
- Renato Porrozzi (ORCID: https://orcid.org/0000-0003-2167-316X)
- Rodrigo Caldas Menezes (ORCID: https://orcid.org/0000-0003-1853-3449)
- Marta de Almeida Santiago
- Tainã Luís de Souza (ORCID: https://orcid.org/0000-0001-7151-3354)
- Fernanda Nazaré Morgado (ORCID: https://orcid.org/0000-0002-7188-251X)
- Fabiano Borges Figueiredo (ORCID: https://orcid.org/0000-0001-6861-0997)
- Artur Augusto Velho Mendes (ORCID: https://orcid.org/0000-0002-7106-797X)
Institutions
- Fundação Carlos Chagas (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1617751
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Fundação Oswaldo Cruz
- Philippine-American Educational Foundation