Comparison of homologous and heterologous vaccination strategies for combating disease caused by Burkholderia pseudomallei
Both strategies provided significant protection against lethal aerosol challenges, and the accumulated data support that a heterologous vaccination strategy employing capsular polysaccharide conjugate and Hcp1 subunits and a live but highly safe capsular polysaccharide-producing surrogate strain of <i>B. thailandensis</i> is an effective and potentially agile prophylactic strategy.
Authors
- David DeShazer (ORCID: https://orcid.org/0000-0003-1758-1238)
- Jennifer L. Shoe
- Zander M. Hedrick
- Jennifer L. Dankmeyer
- Michael L. Davies (ORCID: https://orcid.org/0000-0003-4431-6448)
- Lindsey K. Schmidt
- Nathaniel O. Rill
- Sergei S. Biryukov (ORCID: https://orcid.org/0000-0002-1297-2363)
- Caitlyn E. Orne
- Christopher K. Cote (ORCID: https://orcid.org/0000-0002-1615-5432)
- Ju Qiu (ORCID: https://orcid.org/0000-0002-1543-5678)
- Susan L. Welkos (ORCID: https://orcid.org/0000-0002-7254-3480)
- Mary N. Burtnick (ORCID: https://orcid.org/0000-0001-6763-4348)
- Christopher P. Klimko
- Paul J. Brett (ORCID: https://orcid.org/0000-0002-5555-6714)
- Melissa Hunter
Institutions
- University of Nevada, Reno (US)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1596265
- Citations
- 1
- Primary Topic
- Burkholderia infections and melioidosis
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Defense Threat Reduction Agency