<i>BDNF</i> Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults
Higher physical activity (PA) is associated with lower phosphorylated tau (p-tau181) in brain-derived neurotrophic factor (<i>BDNF</i>) Val66Met Val/Val carriers.In Val/Val carriers, p-tau181 mediated the association of PA and executive function.There was a negative association of PA and glial fibrillary acidic protein (GFAP) in Val/Val male, but not female participants.The neuroprotective benefits of PA may be more pronounced in <i>BDNF</i> Val/Val carriers.There may be a sex-specific PA pathway for neuroinflammation in Val/Val males.
Authors
- Julio C. Rojas (ORCID: https://orcid.org/0000-0002-1308-646X)
- Anna M. VandeBunte (ORCID: https://orcid.org/0000-0002-5167-3358)
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-2917-8297)
- Argentina Lario‐Lago
- Shannon Y. Lee (ORCID: https://orcid.org/0000-0001-6820-1237)
- Brandon Chan (ORCID: https://orcid.org/0000-0002-9450-4220)
- Valentina E. Diaz
- D. Luke Fischer (ORCID: https://orcid.org/0000-0002-5245-3832)
- Jennifer S. Yokoyama (ORCID: https://orcid.org/0000-0001-7274-2634)
- Claire J. Cadwallader (ORCID: https://orcid.org/0000-0003-3449-3803)
- Jessica E. Rexach (ORCID: https://orcid.org/0000-0002-4462-7249)
- Emily W. Paolillo (ORCID: https://orcid.org/0000-0003-4188-6998)
- Rowan Saloner
- Eliana Marisa Ramos (ORCID: https://orcid.org/0009-0003-7982-4415)
- Kaitlin B. Casaletto
- Coty Chen
Institutions
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/trc2.70106
- Citations
- 2
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Alzheimer's Association
- Larry L. Hillblom Foundation
- American Brain Foundation
- American Academy of Neurology
- National Institutes of Health
- University of California, San Francisco
- National Institute on Aging