Biomarker discovery for non-invasive diagnosis of inflammatory bowel disease using blood transcriptomics
Our findings support the use of peripheral blood transcriptomics for IBD diagnosis and demonstrate that a focused three-gene panel can achieve high diagnostic accuracy. The inclusion of RA as an inflammatory control enabled the identification of IBD-specific markers, minimizing confounding from general immune activation. These results provide a practical foundation for developing non-invasive diagnostic tools for clinical use.
Authors
- Anna Meyfour (ORCID: https://orcid.org/0000-0002-7956-9712)
- Mohammad Hossein Derakhshan Nazari (ORCID: https://orcid.org/0000-0002-1598-7640)
- Shabnam Shahrokh (ORCID: https://orcid.org/0000-0002-3420-5608)
- Mahsa Ghorbaninejad (ORCID: https://orcid.org/0000-0003-3694-8912)
Institutions
- Research Institute for Endocrine Sciences (IR)
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1570374
- Citations
- 1
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Shahid Beheshti University of Medical Sciences
- Research Institute for Gastroenterology and Liver Diseases