MiR-221, miR-320a, miR133a, and miR-133b as potential biomarkers in leiomyosarcoma
miR-221, miR-320a, and miR-133a were significantly upregulated in leiomyosarcoma tumor tissue as compared to adjacent non-tumor tissue. There was no significant difference in miRNA expression and ROC curves in primary tumors as compared to local tumors. While not statistically significant, ROC curve of miR-133b suggests a potential role in predicting metastatic risk, warranting subsequent analysis. This study provides evidence for further evaluation of miR-221, miR-320a, miR-133a, and miR-133b as biomarkers in primary diagnosis and assessment of metastatic risk in leiomyosarcoma.
Authors
- Nikolaus Gaßler (ORCID: https://orcid.org/0000-0002-7351-258X)
- Thomas Lehmann (ORCID: https://orcid.org/0000-0003-1104-7923)
- Gunther O. Hofmann (ORCID: https://orcid.org/0000-0003-2261-214X)
- Karin G. Schrenk (ORCID: https://orcid.org/0000-0003-2131-6779)
- Matthias Vogt (ORCID: https://orcid.org/0000-0002-2636-2531)
- Andreas Hochhaus (ORCID: https://orcid.org/0000-0003-0626-0834)
- Andrew J. Walter
- Wolfram Weschenfelder (ORCID: https://orcid.org/0000-0002-4828-1812)
- Mohammed Akhtar (ORCID: https://orcid.org/0000-0002-0722-7967)
- Joachim H. Clement (ORCID: https://orcid.org/0000-0002-6601-2456)
- Yuan Chen (ORCID: https://orcid.org/0009-0008-7270-7669)
- Kathrin Katenkamp
- Christian Spiegel
Institutions
- Universitätsklinikum Erlangen (DE)
- Klinikum Magdeburg (DE)
- Ernst Abbe University of Applied Sciences Jena (DE)
- Jena University Hospital (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-06-20
- DOI
- https://doi.org/10.3389/fonc.2025.1577859
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00