Multi-omics profiling of TGF-β isoforms and regulatory miRNAs in astrocytic tumors reveals TGF-β-3 as a prognostic biomarker
TGF-β-3 is a potent prognostic biomarker in astrocytic tumors and a promising candidate for targeted therapeutic intervention. Regulatory miRNAs such as hsa-miR-2278 and hsa-miR-3196 may serve as molecular modulators of TGF-β signaling and potential adjuncts in personalized glioma therapy. These findings warrant further investigation into miRNA-based therapeutics targeting the TGF-β axis in high-grade gliomas.
Authors
- K Skóra (ORCID: https://orcid.org/0000-0002-3197-6060)
- Dawid Sobański (ORCID: https://orcid.org/0000-0002-5525-6201)
- Beniamin Oskar Grabarek (ORCID: https://orcid.org/0000-0003-1633-7145)
- Rafał Staszkiewicz (ORCID: https://orcid.org/0000-0002-0781-6534)
- Kamil Bryś (ORCID: https://orcid.org/0000-0002-8465-5455)
- Paweł Gogol (ORCID: https://orcid.org/0009-0005-2745-1957)
- Michał M. Masternak (ORCID: https://orcid.org/0000-0002-8483-930X)
- Damian Strojny (ORCID: https://orcid.org/0009-0007-2324-3039)
Institutions
- Jagiellonian University (PL)
- University of Perpetual Help System DALTA (PH)
- Military Hospital (PK)
- Silesian University in Opava (CZ)
- Sefako (Poland) (PL)
- Academy of Fine Arts in Katowice (PL)
- St. Raphael's Hospital (PK)
- Państwowa Akademia Nauk Stosowanych w Przemyślu (PL)
- 1 Military Clinical Hospital with Outpatient Clinic (PL)
- Our Lady of Perpetual Help (US)
- WSB University (PL)
- Andrzej Frycz Modrzewski Krakow University (PL)
- University of Silesia in Katowice (PL)
- University of Rzeszów (PL)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-06-20
- DOI
- https://doi.org/10.3389/fonc.2025.1592685
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94