Ginsenoside Re ameliorates thioacetamide-induced acute liver injury through inhibiting autophagy-NLRP3 inflammasome pathway
This study highlights G-Re as a promising therapeutic candidate for liver injury, acting through inhibition of autophagy and inflammation via the PI3K/AKT/mTOR signaling pathway.
Authors
- Xian Zhou (ORCID: https://orcid.org/0000-0001-8766-8158)
- Yanfang Zheng (ORCID: https://orcid.org/0000-0003-4731-4499)
- Rui Huang (ORCID: https://orcid.org/0000-0003-4045-4130)
- Jing‐Jer Lin (ORCID: https://orcid.org/0000-0001-8250-7398)
- Ruowei Zhao
- Huan Wang (ORCID: https://orcid.org/0009-0008-1962-8670)
- Shaohua Li (ORCID: https://orcid.org/0000-0001-5972-6541)
- Mingqing Huang
- Dennis Chang
Institutions
- Fujian Medical University (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Westmead Institute (AU)
- Western Sydney University (AU)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-20
- DOI
- https://doi.org/10.3389/fphar.2025.1592203
- Citations
- 3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Natural Science Foundation of China
- Fujian University of Traditional Chinese Medicine
- National Key Research and Development Program of China