Total neoadjuvant immunochemotherapy for proficient mismatch repair or microsatellite stable locally advanced rectal cancer
iTNT regimen has significantly improved the CR rate for pMMR/MSS LARC compared to historical standards, with acceptable toxicity. The approach of prioritizing SCRT followed by immunotherapy is a promising strategy for definitive investigation in future studies.
Authors
- Ligong Tang
- Fangyuan Cheng (ORCID: https://orcid.org/0009-0003-9713-1663)
- Xing Li (ORCID: https://orcid.org/0009-0004-7992-9871)
- Yongchao Xu
Institutions
- Zhengzhou University (CN)
- Henan Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1611386
- Citations
- 3
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.41