Green synthesis and sunscreen formulation of silver nanoparticles of corilagin and evaluation of antimicrobial and antioxidant activity

Corilagin, as a gallotannin, is a major active component of many ethnopharmacological plants such as Phyllanthus Niruri L., P. emblica L. and P. urinaria L., etc. from divi-divi (Caesalpinia coriaria). Corilagin was found to exert a variety of pharmacological effects, including anti-tumor, anti-microorganism, antioxidant, hepatoprotective, anti-inflammatory, neuroprotective and cardiovascular protective activities and has been found to be beneficial in managing type Ⅱ diabetes. Nanoparticles are particles of matter which particles size is 1-100 nm in diameter sometimes its large up to 500 nm. Nano particles are not simple molecules itself and therefore composed of three layers i.e. (a) The surface layer, which may be functionalized with a variety of small molecules, metal ions, surfactants and polymers. (b) The shell layer, which is chemically different material from the core in all aspects, and (c) The core, which is essentially the central portion of the NP and usually refers the NP itself. Creams are the topical preparations which can be applied on the skin. Creams are defined as “viscous liquid or semi-solid emulsions of either the oil-in-water or water- in-oil type” dosage forms which consistency varies by oil and water. Creams are used for cosmetic purposes such as cleansing, beautifying, improving appearances, protective or for therapeutic function. These topical formulations are used for the localized effect for the delivery of the drug into the underlying layer of the skin or the mucous membrane. The study showed that formulation F2 was found to be more stable with high SPF value, proving a better sunscreen cream.