Enhancement of retinal Müller glia’s phagocytic activity against hard exudates by conbercept via activation of PPARγ-CD36 axis in diabetic retinopathy
Conbercept reduces HEs in DR by enhancing Müller glia phagocytosis possibly through activating PPARγ-CD36 axis, which is mediated by inhibition of VEGF signaling. Modulation of Müller glia phagocytic capacity might provide a novel therapeutic strategy to treat DR and DME.
Authors
- Xiao-Sa Li
- Yanchun Zhang (ORCID: https://orcid.org/0000-0002-5094-5980)
- Jingfa Zhang (ORCID: https://orcid.org/0000-0003-0601-4342)
- Hai Xie
- Chaoyang Zhang (ORCID: https://orcid.org/0000-0001-6816-3840)
- Yingying Zhu (ORCID: https://orcid.org/0000-0003-2631-9610)
- Yinping Liu (ORCID: https://orcid.org/0000-0002-1530-7692)
Institutions
- Nantong University (CN)
- Soochow University (CN)
- Shaanxi Provincial People's Hospital (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Shanghai First People's Hospital (CN)
- Massachusetts Eye Research and Surgery Institute (US)
- He Eye Hospital (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- International Journal of Ophthalmology
- Published
- 2025-06-20
- DOI
- https://doi.org/10.18240/ijo.2025.07.07
- Citations
- 1
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- National Natural Science Foundation of China