Sex differences in the network structures of depressive symptom profiles in Asian patients with depressive disorders: findings from the Research on Asian Psychotropic Patterns for Antidepressants, Phase 3
The study highlights the sex-specific differences in depressive symptom networks across Asian countries. The results revealed that low self-confidence and loss of interest are the main symptoms of depression in Asian men and women, respectively. The network connections were more localised in men, whereas women showed a more diverse network. Among the Asian subgroups analysed, only East Asians exhibited significant differences in network structure. The considerable effects of neurovegetative symptoms in men may indicate potential neurobiological underpinnings of depression in the East Asian population.
Authors
- Mian‐Yoon Chong (ORCID: https://orcid.org/0000-0001-5836-0509)
- Pornjira Pariwatcharakul (ORCID: https://orcid.org/0000-0003-0228-3043)
- Andi Jayalangkara Tanra (ORCID: https://orcid.org/0000-0002-3962-4190)
- Eunsoo Moon (ORCID: https://orcid.org/0000-0002-8863-3413)
- Norman Sartorius (ORCID: https://orcid.org/0000-0001-8708-6289)
- Jeongha Lee (ORCID: https://orcid.org/0009-0007-2171-313X)
- Hyung‐Jun Yoon (ORCID: https://orcid.org/0000-0003-3087-8853)
- Jae-Hon Lee (ORCID: https://orcid.org/0000-0002-9490-2050)
- Yangsik Kim (ORCID: https://orcid.org/0000-0003-1841-727X)
- Takahiro A. Kato (ORCID: https://orcid.org/0000-0001-5169-2930)
- Amir Hossein Jalali Nadoushan (ORCID: https://orcid.org/0000-0002-0819-3981)
- Seon‐Cheol Park (ORCID: https://orcid.org/0000-0003-3691-4624)
- Tianmei Si (ORCID: https://orcid.org/0000-0001-9823-2720)
- Naotaka Shinfuku (ORCID: https://orcid.org/0000-0002-7390-9077)
- Afzal Javed (ORCID: https://orcid.org/0000-0003-2518-0688)
- Tae Young Choi (ORCID: https://orcid.org/0000-0003-2677-9297)
- Shih‐Ku Lin (ORCID: https://orcid.org/0000-0002-5123-0389)
- Kang Sim (ORCID: https://orcid.org/0000-0003-3209-9626)
- Narae Jeong (ORCID: https://orcid.org/0000-0003-4407-678X)
- Kok Yoon Chee (ORCID: https://orcid.org/0000-0002-5755-9572)
- Roy Abraham Kallivayalil (ORCID: https://orcid.org/0000-0002-1991-3796)
- Toshiya Inada (ORCID: https://orcid.org/0000-0002-8427-5639)
- Hyun-Soo Kim (ORCID: https://orcid.org/0000-0003-2171-4400)
- Daeho Kim (ORCID: https://orcid.org/0000-0002-6834-6775)
- Sungwon Jung (ORCID: https://orcid.org/0000-0002-5332-5947)
- Hyun Ju Yang (ORCID: https://orcid.org/0000-0001-8175-6122)
- Seonjae Lee (ORCID: https://orcid.org/0009-0003-6535-3843)
- Han Seul Kim (ORCID: https://orcid.org/0009-0007-7240-1742)
Institutions
- Thiruvalluvar University (IN)
- Western University (CA)
- Siriraj Hospital (TH)
- Seinan Gakuin University (JP)
- Iran University of Medical Sciences (IR)
- Inha University (KR)
- Peking University (CN)
- Hokkaido University (JP)
- Mahidol University (TH)
- Hospital Kuala Lumpur (MY)
- Fountain Way (GB)
- Action for ME (GB)
- New Generation University College (ET)
- Pushpagiri Medical College (IN)
- Taipei Municipal YangMing Hospital (TW)
- Sultan Ismail Specialist Hospital (MY)
- Daegu Catholic University (KR)
- Chosun University Hospital (KR)
- The Geneva Association (CH)
- Linkou Chang Gung Memorial Hospital (TW)
- Taipei City Hospital (TW)
- National University College (PR)
- Hanyang University Guri Hospital (KR)
- Bali Psychiatric Center (TW)
- Institute of Mental Health (SG)
- Spire Regency Hospital (GB)
- Hanyang University Medical Center (KR)
- Inha University Hospital (KR)
- Peking University Sixth Hospital (CN)
- Jeju National University Hospital (KR)
- Hanyang University (KR)
- Pusan National University (KR)
- Dong-A University (KR)
- Keimyung University (KR)
- Nagoya University (JP)
- Jeju National University (KR)
- Daegu University (KR)
- Hasanuddin University (ID)
Publication Details
- Journal
- Acta Neuropsychiatrica
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/neu.2025.10020
- Citations
- 1
- Primary Topic
- Mental Health Research Topics
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- University of Cambridge
- National Research Foundation
- National Research Foundation of Korea