Visible-light-mediated late-stage N-functionalization of unprotected peptides: introducing the aza-Zimmerman–O'Connell–Griffin reaction

A sustainable, reagent-free method for amide synthesis and peptide functionalization via photoinduced ZOG rearrangement. High-yielding, purification without chromatography, and driven solely by light—ideal for greener peptide modification.

Authors

Ganesh S. Ghotekar (ORCID: https://orcid.org/0000-0002-8798-8597)
August Runemark (ORCID: https://orcid.org/0000-0002-3650-1881)
Henrik Sundén (ORCID: https://orcid.org/0000-0001-6202-7557)
Ganesh Shinde
Walter Graf
Sara P. Garcia (ORCID: https://orcid.org/0000-0003-3312-6454)

Institutions

University of Gothenburg (SE)

Publication Details

Journal: Green Chemistry
Published: 2025-01-01
DOI: https://doi.org/10.1039/d5gc02108a
Primary Topic: Radical Photochemical Reactions
Type: article
Field-Weighted Citation Impact: 0.00

Funders

European Commission
Science for Life Laboratory

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article

Visible-light-mediated late-stage N-functionalization of unprotected peptides: introducing the aza-Zimmerman–O'Connell–Griffin reaction

Ganesh S. Ghotekar, August Runemark, Henrik Sundén, Ganesh Shinde et al.

Jan 1, 2025

Green Chemistry

Radical Photochemical Reactions

article

Visible-light-mediated late-stage N-functionalization of unprotected peptides: introducing the aza-Zimmerman–O'Connell–Griffin reaction

Ganesh S. Ghotekar, August Runemark, Henrik Sundén, Ganesh Shinde, Walter Graf, Sara P. Garcia

January 1, 2025article en

Abstract

A sustainable, reagent-free method for amide synthesis and peptide functionalization via photoinduced ZOG rearrangement. High-yielding, purification without chromatography, and driven solely by light—ideal for greener peptide modification.

Green ChemistryVol. 27(27)

University of Gothenburg (SE)

European Commission, Science for Life Laboratory

Openalex Percentile: Top 89%

Radical Photochemical Reactions

DOI Open Access PDF OpenAlex

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Visible-light-mediated late-stage N-functionalization of unprotected peptides: introducing the aza-Zimmerman–O'Connell–Griffin reaction — Ganesh S. Ghotekar, August Runemark, et al. · Green Chemistry (2025) | TGRS Research Map | TGRS