The legacy effect of early HbA1c control on microvascular complications and hospital admissions in type 2 diabetes: findings from a large UK study

The risk of microvascular complications was lowest when HbA1c levels were within the non-diabetic range and increased with higher HbA1c levels. The risk of hospital admission was significantly elevated in individuals with HbA1c levels below 6.5%, suggesting a potential U-shaped association, although the increased risk at higher HbA1c levels did not reach statistical significance. This highlights the importance of maintaining individualised HbA1c targets in the management of T2D from diagnosis to prevent these complications.

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Publication Details

Journal
Therapeutic Advances in Endocrinology and Metabolism
Published
2025-06-20
DOI
https://doi.org/10.1177/20420188251350897
Citations
3
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
3.88

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article

The legacy effect of early HbA1c control on microvascular complications and hospital admissions in type 2 diabetes: findings from a large UK study

Rami Aldafas, ISKANDAR RAUF IDRIS, Thomas Crabtree, Jason Gordon et al.
3 citations
Therapeutic Advances in Endocrinology and Metabolism
Diabetes Treatment and Management
3.88
article

The legacy effect of early HbA1c control on microvascular complications and hospital admissions in type 2 diabetes: findings from a large UK study

Rami Aldafas, ISKANDAR RAUF IDRIS, Thomas Crabtree, Jason Gordon, Yana Vinogradova
article en
3 citations

Abstract

The risk of microvascular complications was lowest when HbA1c levels were within the non-diabetic range and increased with higher HbA1c levels. The risk of hospital admission was significantly elevated in individuals with HbA1c levels below 6.5%, suggesting a potential U-shaped association, although the increased risk at higher HbA1c levels did not reach statistical significance. This highlights the importance of maintaining individualised HbA1c targets in the management of T2D from diagnosis to prevent these complications.

Therapeutic Advances in Endocrinology and MetabolismVol. 16
Saudi Electronic University (SA), University of Nottingham (GB), Royal Derby Hospital (GB)
NIHR Nottingham Biomedical Research Centre
Good health and well-being
Openalex Percentile: Top 6%
Diabetes Treatment and Management
3.88
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