The legacy effect of early HbA1c control on microvascular complications and hospital admissions in type 2 diabetes: findings from a large UK study
The risk of microvascular complications was lowest when HbA1c levels were within the non-diabetic range and increased with higher HbA1c levels. The risk of hospital admission was significantly elevated in individuals with HbA1c levels below 6.5%, suggesting a potential U-shaped association, although the increased risk at higher HbA1c levels did not reach statistical significance. This highlights the importance of maintaining individualised HbA1c targets in the management of T2D from diagnosis to prevent these complications.
Authors
- Rami Aldafas
- ISKANDAR RAUF IDRIS (ORCID: https://orcid.org/0000-0002-7548-8288)
- Thomas Crabtree (ORCID: https://orcid.org/0000-0001-7886-8262)
- Jason Gordon (ORCID: https://orcid.org/0000-0001-8635-742X)
- Yana Vinogradova (ORCID: https://orcid.org/0000-0002-3030-5257)
Institutions
- Saudi Electronic University (SA)
- University of Nottingham (GB)
- Royal Derby Hospital (GB)
Publication Details
- Journal
- Therapeutic Advances in Endocrinology and Metabolism
- Published
- 2025-06-20
- DOI
- https://doi.org/10.1177/20420188251350897
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- NIHR Nottingham Biomedical Research Centre