Predicting Weight Loss After Vertical Sleeve Gastrectomy Using a Whole-genome Sequencing–derived Polygenic Risk Score in the All of Us Cohort
Use of short-read whole-genome sequencing from All of Us (AoU) can be effectively used to generate PRS to enhance predictive WL accuracy. This work has implications for outcomes of both bariatric surgery and other surgical procedures.
Authors
- Yu Hou
- Sayeed Ikramuddin (ORCID: https://orcid.org/0000-0003-3088-7952)
- Daniel B. Leslie (ORCID: https://orcid.org/0000-0002-6167-8531)
- Jinhua Wang (ORCID: https://orcid.org/0000-0001-8367-0787)
- Rui Zhang (ORCID: https://orcid.org/0000-0001-8258-3585)
Institutions
- University of Minnesota (US)
- University of Minnesota System (US)
- University of Minnesota Medical Center (US)
Publication Details
- Journal
- Annals of Surgery
- Published
- 2025-06-20
- DOI
- https://doi.org/10.1097/sla.0000000000006809
- Primary Topic
- Bariatric Surgery and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00