Monitoring Hematologic Parameters in Pediatric Oncology Patients Diagnosed With Sepsis or Febrile Neutropenia: A Tertiary Center Experience

This study analyzes hematologic and inflammatory parameters in pediatric oncology patients with febrile neutropenia (FN) or sepsis, aiming to identify simple diagnostic markers. Conducted in a tertiary center, 150 infectious episodes were evaluated. Results showed statistically significant differences in leukocyte (G1: 4.95-7.03, p=0.01/G2: 4.91-7.01, p=0.01) and neutrophil counts (G1: 3.10-4.05, p=003/G2: 3.22-5.70, p=0.02) after treatment, especially in sepsis cases, with a statistically significant decrease in C-reactive protein (p=0.01) and procalcitonin (p=0.01) post-therapy. Although fibrinogen showed limited diagnostic value, the observed variation may still reflect a relevant pattern, as suggested in prior research. These findings highlight the importance of accessible biomarkers in guiding early diagnosis and management in resource-limited healthcare settings.