Chemical and Mechanistic Prediction Analysis of Anti-obesity Propertiesof Guang Hawthorn (Malus doumeri) Leaves using Network Analysis
This research demonstrates the anti-obesity potential of sieboldin and kumatakenin β-7-O-glucoside in HML. These compounds, along with phlorizin, modulated the PI3K-Akt and FoxO signaling pathways and proteoglycan synthesis, contributing to the reversal of obesityrelated effects. These findings suggest that M. doumeri leaf extracts may offer a promising natural therapeutic approach for obesity management.
Authors
- Danna Huang (ORCID: https://orcid.org/0000-0002-2126-246X)
- Li Jiang (ORCID: https://orcid.org/0000-0001-7351-1811)
- Ming-sheng Lan
- Chao Luo (ORCID: https://orcid.org/0000-0002-7007-1440)
- Wuwei Wu (ORCID: https://orcid.org/0000-0002-8913-478X)
- Guibing Meng
- Yu Liu (ORCID: https://orcid.org/0000-0001-6012-5305)
- Lu Chen (ORCID: https://orcid.org/0000-0001-9708-341X)
- Lijun Yin (ORCID: https://orcid.org/0009-0000-3664-8157)
- Yu Pan (ORCID: https://orcid.org/0000-0001-6704-4946)
Institutions
- Shanghai Mental Health Center (CN)
- Guangxi Medicinal Botanical Garden (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-06-18
- DOI
- https://doi.org/10.2174/0113862073375434250529170324
- Citations
- 1
- Primary Topic
- Botanical Studies and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.75