N-(2-((2-(1H-indol-3-yl)ethyl)carbamoyl)phenyl)furan-2-carboxamide

In the present study, we describe the synthesis of N-(2-((2-(1H-indol-3-yl)ethyl)carbamoyl)phenyl)furan-2-carboxamide via a two-step reaction sequence. Initially, isatoic anhydride was reacted with tryptamine to afford the corresponding intermediate, which was subsequently subjected to acylation using furan-2-carbonyl chloride. The final product was comprehensively characterized by melting point analysis, 1H and 13C NMR, HSQC, IR, and MS spectrometry. The combined spectroscopic and analytical data unequivocally confirm the successful synthesis and structural integrity of the target compound.

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Publication Details

Journal
Molbank
Published
2025-06-20
DOI
https://doi.org/10.3390/m2025
Primary Topic
Synthesis and Biological Evaluation
Type
article
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article

N-(2-((2-(1H-indol-3-yl)ethyl)carbamoyl)phenyl)furan-2-carboxamide

Iliyan Ivanov, Diyana Dimitrova, Dimitar G. Bojilov, Stanimir P. Manolov
Molbank
Synthesis and Biological Evaluation
article

N-(2-((2-(1H-indol-3-yl)ethyl)carbamoyl)phenyl)furan-2-carboxamide

Iliyan Ivanov, Diyana Dimitrova, Dimitar G. Bojilov, Stanimir P. Manolov
article en

Abstract

In the present study, we describe the synthesis of N-(2-((2-(1H-indol-3-yl)ethyl)carbamoyl)phenyl)furan-2-carboxamide via a two-step reaction sequence. Initially, isatoic anhydride was reacted with tryptamine to afford the corresponding intermediate, which was subsequently subjected to acylation using furan-2-carbonyl chloride. The final product was comprehensively characterized by melting point analysis, 1H and 13C NMR, HSQC, IR, and MS spectrometry. The combined spectroscopic and analytical data unequivocally confirm the successful synthesis and structural integrity of the target compound.

MolbankVol. 2025(3)
Plovdiv University (BG)
Clean water and sanitation
Openalex Percentile: Top 89%
Synthesis and Biological Evaluation
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N-(2-((2-(1H-indol-3-yl)ethyl)carbamoyl)phenyl)furan-2-carboxamide — Iliyan Ivanov, Diyana Dimitrova, et al. · Molbank (2025) | TGRS Research Map | TGRS