A Nano‐Electro‐Platform Enabling Evolutionary Screening and Remodeling of Tumor Cells for Metastasis Inhibition

Tumor metastasis remains the leading cause of mortality among cancer patients. Addressing this challenge necessitates the development of effective strategies for targeted drug delivery and therapy. Given that metastatic lesions are primarily driven by highly aggressive tumor cell subpopulations, in-depth study of these cells and further guiding design of targeted therapeutics, play deterministic roles in metastasis inhibition. Herein, a nano-electro-platform is shown that enables non-invasive screening of aggressive cell subpopulations from heterogeneous tumor samples. Single-cell sequencing further reveals immune evasion pathways associated with their aggressive behavior. Targeting the screened aggressive cells, the platform implements a unique nanopore-focused electric field, which genetically remodels the cells to generate extracellular vesicles (EVs) with significantly enhanced tumor-targeting and therapeutic capabilities. The engineered EVs effectively activate macrophages and T cells, leading to robust tumor cell elimination and metastasis inhibition in lung cancer metastasis models. These highlight a versatile, multidisciplinary technique adopting a new path toward deep understanding and treating metastasis.

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Publication Details

Journal
Advanced Science
Published
2025-06-20
DOI
https://doi.org/10.1002/advs.202507684
Citations
2
Primary Topic
Extracellular vesicles in disease
Type
article
Field-Weighted Citation Impact
1.61

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article

A Nano‐Electro‐Platform Enabling Evolutionary Screening and Remodeling of Tumor Cells for Metastasis Inhibition

Xiaowei Xiang, Chaorui Wu, Dedong Yin, Zaizai Dong et al.
2 citations
Advanced Science
Extracellular vesicles in disease
1.61
article

A Nano‐Electro‐Platform Enabling Evolutionary Screening and Remodeling of Tumor Cells for Metastasis Inhibition

Xiaowei Xiang, Chaorui Wu, Dedong Yin, Zaizai Dong, Feng Yao, Yan Shi, Han Wu, Hong Sun, Lingqian Chang, Yuqiong Wang, Jing Zhang, Yihang Tong, Ao Xiao, Bing Liu, Feng Liu, Long Cheng, Rongtai Su, Kuan Yang, Nan Wu, Xi Chen, Chengzheng Tai
article en
2 citations

Abstract

Tumor metastasis remains the leading cause of mortality among cancer patients. Addressing this challenge necessitates the development of effective strategies for targeted drug delivery and therapy. Given that metastatic lesions are primarily driven by highly aggressive tumor cell subpopulations, in-depth study of these cells and further guiding design of targeted therapeutics, play deterministic roles in metastasis inhibition. Herein, a nano-electro-platform is shown that enables non-invasive screening of aggressive cell subpopulations from heterogeneous tumor samples. Single-cell sequencing further reveals immune evasion pathways associated with their aggressive behavior. Targeting the screened aggressive cells, the platform implements a unique nanopore-focused electric field, which genetically remodels the cells to generate extracellular vesicles (EVs) with significantly enhanced tumor-targeting and therapeutic capabilities. The engineered EVs effectively activate macrophages and T cells, leading to robust tumor cell elimination and metastasis inhibition in lung cancer metastasis models. These highlight a versatile, multidisciplinary technique adopting a new path toward deep understanding and treating metastasis.

Advanced ScienceVol. 12(34)
Qingdao University (CN), Qingdao Agricultural University (CN), Capital Medical University (CN), Anhui Medical University (CN), Peking University (CN), Peking University Cancer Hospital (CN), Beijing Chest Hospital (CN), Beijing Friendship Hospital (CN), Ministry of Education (ET), Beihang University (CN)
National Natural Science Foundation of China, Peking University, Fundamental Research Funds for the Central Universities, National Science Fund for Distinguished Young Scholars
Good health and well-being
Openalex Percentile: Top 16%
Extracellular vesicles in disease
1.61
DOIOpen Access PDFOpenAlex
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