Deep Brain Stimulation for <scp> <i>VPS16</i> </scp> ‐Related Dystonia: A Multicenter Study
DBS was an effective treatment for three-quarters of patients with pathogenic VPS16 variants in our cohort. Mean motor improvement was most pronounced at the 1-year FU, but persisted at the last FU despite disease progression. ANN NEUROL 2025;98:711-725.
Authors
- Veronika Jurková
- Katja Lohmann (ORCID: https://orcid.org/0000-0002-5121-1460)
- Petra Havránková (ORCID: https://orcid.org/0000-0002-7731-5129)
- Simone Zittel (ORCID: https://orcid.org/0000-0002-3767-6376)
- Barbara Garavaglia
- Manju A. Kurian (ORCID: https://orcid.org/0000-0003-3529-5075)
- Marina A.J. Tijssen (ORCID: https://orcid.org/0000-0001-5783-571X)
- Thomas Foltynie (ORCID: https://orcid.org/0000-0003-0752-1813)
- Kamil Knorovsky
- Vladimír Haň (ORCID: https://orcid.org/0000-0003-1942-3778)
- Jens Volkmann (ORCID: https://orcid.org/0000-0002-9570-593X)
- Alberto Mazzoni (ORCID: https://orcid.org/0000-0002-9632-1831)
- Ahmet Kaymak (ORCID: https://orcid.org/0000-0003-1239-6359)
- Veronika Magocova
- Patricia Limousin (ORCID: https://orcid.org/0000-0001-5668-5545)
- Claudio Baiata (ORCID: https://orcid.org/0009-0008-6333-0679)
- Ľuboš Ambro (ORCID: https://orcid.org/0000-0003-4398-1665)
- David Murphy (ORCID: https://orcid.org/0000-0003-2946-0353)
- Liesanne M. Centen (ORCID: https://orcid.org/0000-0002-5415-3526)
- Jan Niklas Petry‐Schmelzer (ORCID: https://orcid.org/0000-0003-0749-3840)
- Harith Akram (ORCID: https://orcid.org/0000-0002-2899-628X)
- Robert Jech (ORCID: https://orcid.org/0000-0002-9732-8947)
- Elena Moro (ORCID: https://orcid.org/0000-0002-7968-5908)
- Martje E. van Egmond (ORCID: https://orcid.org/0000-0003-2648-6937)
- Tatiana Svoreňová
- Miriam Ostrožovičová (ORCID: https://orcid.org/0000-0003-1519-1535)
- Roberto Eleopra (ORCID: https://orcid.org/0000-0002-6035-9715)
- Luigi Romito (ORCID: https://orcid.org/0000-0002-6772-1035)
- Wolfgang Hamel (ORCID: https://orcid.org/0000-0002-3890-502X)
- Nico Golfrè Andreasi (ORCID: https://orcid.org/0000-0003-3555-5367)
- Steffen Paschen (ORCID: https://orcid.org/0000-0002-9306-8332)
- Michael T. Barbe (ORCID: https://orcid.org/0000-0003-1149-8054)
- Henry Houlden (ORCID: https://orcid.org/0000-0002-2866-7777)
- Michael Zech (ORCID: https://orcid.org/0000-0002-9586-0390)
- Matěj Škorvánek (ORCID: https://orcid.org/0000-0001-5497-8715)
- Ludvic Zrinzo (ORCID: https://orcid.org/0000-0002-6013-4946)
- Alberto Albanese (ORCID: https://orcid.org/0000-0002-5864-0006)
- Chiara Reale (ORCID: https://orcid.org/0000-0002-7493-758X)
- Francesca Magrinelli (ORCID: https://orcid.org/0000-0003-4706-6245)
- Doreen Gruber (ORCID: https://orcid.org/0009-0009-4335-4718)
- Eoin Mulroy (ORCID: https://orcid.org/0000-0002-0823-8916)
- Kirsten E. Zeuner
- Vincenzo Levi
- Giovanna Zorzi
- Laura Cif
- Aurelia Kollova
Institutions
- University Medical Center Groningen (NL)
- Universität Hamburg (DE)
- Scuola Superiore Sant'Anna (IT)
- Queen Mary University of London (GB)
- University of Groningen (NL)
- University of Cologne (DE)
- University of Pavol Jozef Šafárik (SK)
- Charles University (CZ)
- University of Würzburg (DE)
- Great Ormond Street Hospital (GB)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Helmholtz Zentrum München (DE)
- Fondazione Istituto Neurologico Nazionale Casimiro Mondino (IT)
- University Medical Center Hamburg-Eppendorf (DE)
- Univerzitná Nemocnica Louisa Pasteura (SK)
- Hôpital Gui de Chauliac (FR)
- University Hospital Schleswig-Holstein (DE)
- Munich Cluster for Systems Neurology (DE)
- Neurologisches Fachkrankenhaus für Bewegungsstörungen/Parkinson (DE)
- Institute for Advanced Study (DE)
- Grenoble Institute of Neurosciences (FR)
- National Hospital for Neurology and Neurosurgery (GB)
- University Hospital Cologne (DE)
- Vitenparken (NO)
- General University Hospital in Prague (CZ)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Bioscience (Slovakia) (SK)
- University College London (GB)
- Technical University of Munich (DE)
- Université Grenoble Alpes (FR)
- University of Lübeck (DE)
- University of Lausanne (CH)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-06-20
- DOI
- https://doi.org/10.1002/ana.27290
- Citations
- 5
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.95
Funders
- Michael J. Fox Foundation for Parkinson's Research
- American Parkinson Disease Association
- Australian Government
- National Institute for Health and Care Research
- Parkinson's UK
- University College London
- European Commission
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Else Kröner-Fresenius-Stiftung
- Ministero della Salute
- Fondazione Pierfranco e Luisa Mariani
- Agentúra na Podporu Výskumu a Vývoja
- Technische Universität München
- UCLH Biomedical Research Centre
- Institute for Advanced Study, Technische Universität München