Analysis and simulation of a novel stochastic RNA silencing model

The current work aims to investigate how random environmental fluctuations affect the dynamics of the RNA Silencing model. To capture this complexity, a novel stochastic RNA Silencing model is proposed by incorporating four distinct white noise terms into key system parameters. Unlike previous deterministic approaches, our model explicitly accounts for stochastic perturbations using Brownian motion processes. A comprehensive analysis of both the deterministic as well as the stochastic one are presented. Employing Lyapunov analysis, the stochastic system yields a unique global positive solution for any initial value, ensuring its biological relevance. Lastly, numerical simulations based on the Milstein's higher-order-method are conducted for the two models. The findings highlight the significant influence of stochasticity on RNA silencing dynamics, offering new insights into the stability and behavior of gene regulatory processes under random fluctuations.

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Publication Details

Journal
Scientific Reports
Published
2025-06-20
DOI
https://doi.org/10.1038/s41598-025-04142-w
Primary Topic
RNA Research and Splicing
Type
article
Field-Weighted Citation Impact
0.00

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article

Analysis and simulation of a novel stochastic RNA silencing model

Ragaa Ahmed, Hillal M. Elshehabey
Scientific Reports
RNA Research and Splicing
article

Analysis and simulation of a novel stochastic RNA silencing model

Ragaa Ahmed, Hillal M. Elshehabey
article en

Abstract

The current work aims to investigate how random environmental fluctuations affect the dynamics of the RNA Silencing model. To capture this complexity, a novel stochastic RNA Silencing model is proposed by incorporating four distinct white noise terms into key system parameters. Unlike previous deterministic approaches, our model explicitly accounts for stochastic perturbations using Brownian motion processes. A comprehensive analysis of both the deterministic as well as the stochastic one are presented. Employing Lyapunov analysis, the stochastic system yields a unique global positive solution for any initial value, ensuring its biological relevance. Lastly, numerical simulations based on the Milstein's higher-order-method are conducted for the two models. The findings highlight the significant influence of stochasticity on RNA silencing dynamics, offering new insights into the stability and behavior of gene regulatory processes under random fluctuations.

Scientific ReportsVol. 15(1)
South Valley University (EG)
Science and Technology Development Fund, South Valley University
Life in Land
Openalex Percentile: Top 87%
RNA Research and Splicing
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