Multivalent COBRA Hemagglutinin and Neuraminidase Influenza Vaccines Adjuvanted with TLR9 Agonist CpG 1018
Overall, CpG 1018 adjuvanted COBRA HA/NA elicited enhanced protective antibodies compared to the unadjuvanted vaccine against several drifted H1N1 and H3N2 influenza viruses in pre-immune mice that were either intramuscularly or intranasally vaccinated with a balanced Th1/Th2 immune response.
Authors
- Pedro L. Sánchez (ORCID: https://orcid.org/0000-0002-1402-0526)
- Ted M. Ross (ORCID: https://orcid.org/0000-0003-1947-7469)
- Alisson Lynch
Institutions
- University of Georgia (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Cleveland Clinic Florida (US)
Publication Details
- Journal
- Vaccines
- Published
- 2025-06-20
- DOI
- https://doi.org/10.3390/vaccines13070662
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Georgia Research Alliance
- National Institutes of Health