Selenium-Substituted BOIMPY for Enhanced Photodynamic Therapy
Seleno-substituted bis-(boron difluoride)-8-imidazo-dipyrro-methene (BOIMPY) derivatives displayed improved photophysical features over twisted-BOIMPY, such as greater Stokes shifts, while compromising radiative relaxation and intersystem crossing, making them suitable for imaging-guided photodynamic therapy (PDT). One exhibited improved Type I and Type II PDT against cancer cells when activated by near-infrared light. Its potential as a targeted PDT agent for cancer treatment is demonstrated by its remarkable phototoxicity in the nanomolar range and minimal dark toxicity.
Authors
- Kenika Khotchasanthong (ORCID: https://orcid.org/0000-0002-5982-1650)
- Kantapat Chansaenpak (ORCID: https://orcid.org/0000-0002-5462-9897)
- Tunyawat Khrootkaew
- Prapassara Muangsopa
- Kittipong Chainok (ORCID: https://orcid.org/0000-0003-1486-9164)
- Anyanee Kamkaew (ORCID: https://orcid.org/0000-0003-1203-2686)
- Sorachat Tharamak (ORCID: https://orcid.org/0009-0008-5278-5985)
- Bongkot Ouengwanarat
- Kevin Burgess (ORCID: https://orcid.org/0000-0001-6597-1842)
Institutions
- Thammasat University (TH)
- National Science and Technology Development Agency (TH)
- Kasetsart University (TH)
- Mitchell Institute (US)
- Shanghai Institute for Science of Science (CN)
- National Nanotechnology Center (TH)
- Resonance Research (United States) (US)
- Suranaree University of Technology (TH)
- Texas A&M University (US)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2025-06-20
- DOI
- https://doi.org/10.1021/acsmedchemlett.5c00174
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Welch Foundation
- Suranaree University of Technology
- National Research Council of Thailand
- Thailand Science Research and Innovation
- National Institute of Neurological Disorders and Stroke