Evaluation of whole-brain radiotherapy in patients with non-lung cancer brain metastases at Viet Tiep Friendship Hospital from 1/2022 to 12/2023

Objective: To evaluate the outcomes of whole-brain radiotherapy (WBRT) in patients with brain metastases from non-lung cancer at Viet Tiep Friendship Hospital between January 2022 and December 2023. Methods: This study described and combined prospective and retrospective analyses of 124 patients with brain metastases from non-lung cancer treated with WBRT at a dose of 30 Gy/10 sessions. Results: Patients with brain metastases typically originate from breast or colorectal cancer. Symptomatic improvement was achieved in 70-80% of cases, physical response in 55-70%, and imaging response in 62.07%. Response rates were significantly influenced by the extent of brain metastasis, overall health status, and progression of the primary tumor or other metastatic sites. Side effects were mild and easily managed. Conclusion: WBRT for brain metastases is a safe method for improving overall survival and significantly reducing symptoms. However, the extent of brain metastasis, KPS score, and control of the primary tumor significantly affected the response rates and survival times.