Anal squamous cell carcinoma with mucinous microcysts represents anal gland duct differentiation

SCC-MM represents anal gland duct differentiation and can be reliably distinguished from its closest and commonest differential diagnosis, basaloid SCC, by the histological identification of mucin containing cysts and by immunohistochemistry for MUC5AC, GATA3 and p63. This distinction may be clinically important for the prognostication and pathological staging of anal carcinoma in excision specimens.

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Publication Details

Journal
Histopathology
Published
2025-06-20
DOI
https://doi.org/10.1111/his.15500
Primary Topic
Colorectal and Anal Carcinomas
Type
article
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article

Anal squamous cell carcinoma with mucinous microcysts represents anal gland duct differentiation

Guzin Bostanci, Newton A C S Wong
Histopathology
Colorectal and Anal Carcinomas
article

Anal squamous cell carcinoma with mucinous microcysts represents anal gland duct differentiation

Guzin Bostanci, Newton A C S Wong
article en

Abstract

SCC-MM represents anal gland duct differentiation and can be reliably distinguished from its closest and commonest differential diagnosis, basaloid SCC, by the histological identification of mucin containing cysts and by immunohistochemistry for MUC5AC, GATA3 and p63. This distinction may be clinically important for the prognostication and pathological staging of anal carcinoma in excision specimens.

HistopathologyVol. 87(3)
Southmead Hospital (GB)
No poverty
Openalex Percentile: Top 75%
Colorectal and Anal Carcinomas
DOIOpen Access PDFOpenAlex
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Anal squamous cell carcinoma with mucinous microcysts represents anal gland duct differentiation — Guzin Bostanci, Newton A C S Wong · Histopathology (2025) | TGRS Research Map | TGRS