Drug resistance profile of Mycobacterium tuberculosis complex isolated from pulmonary tuberculosis patients and their household contacts in central Ethiopia
Nearly one-third of the household contacts have discordant drug-resistance profiles from the index patients. This study offers compelling proof that it is not advisable to treat close contacts without DST results based on the DST results of the supposed source case. The low drug resistance rate to new oral second-line drugs in this study did not guarantee the absence of resistance to each drug.
Authors
- Balako Gumi
- Solomon H Mariam (ORCID: https://orcid.org/0000-0002-5213-6044)
- Getu Diriba (ORCID: https://orcid.org/0000-0002-0166-682X)
- Getachew Seid (ORCID: https://orcid.org/0000-0002-8708-386X)
- Ayinalem Alemu (ORCID: https://orcid.org/0000-0001-5307-8774)
- Betselot Zerihun (ORCID: https://orcid.org/0000-0003-4277-2247)
- Gemechu Tadesse (ORCID: https://orcid.org/0009-0009-8417-1651)
Institutions
- Ethiopian Public Health Institute (ET)
- Addis Ababa University (ET)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-06-20
- DOI
- https://doi.org/10.1186/s12879-025-11220-x
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Addis Ababa University