System modeling and image reconstruction algorithm optimization for a Compton camera for hadron therapy range verification

Abstract Compton cameras are electronically collimated devices which offer a compact solution for multi-energy gamma-ray imaging. For this reason, such devices are being investigated as potential tools to achieve online range verification in hadron therapy, through the so-called Prompt Gamma imaging technique. However, this application is notably challenging, entailing the need of complex image reconstruction procedures and requiring excellent detector performance in order to achieve sufficient image quality. In this work we recapitulate the steps made in the recent years in system modeling and adaptation of existing image reconstruction algorithms towards the full exploitation of MACACO, a multi-layer Compton telescope under development at the IRIS group of IFIC (Valencia).