Moving beyond the syndrome: how can acute kidney injury phenotypes help?

There are prognostic and treatment benefits to AKI phenotyping and subphenotyping which allow us to provide a customized approach to AKI care. Challenges currently exist to implementation of AKI phenotyping at the bedside but ongoing projects are already seeking solutions for feasible bedside identification of subphenotypes using machine-learning or point-of-care biomarker assays. Future research in this area will focus on the ability to recognize and link endotypes, subphenotypes and phenotypes in AKI.