PET/CT imaging of esophageal cancer targeting tumor cell specific αvβ6-integrin expression
High (99%) membranous expression frequency and density on tumor cells underscores the potential of αvβ6-integrin as a theranostic target in ESCC, suggesting that αvβ6-integrin PET/CT imaging may adopt a role in re-staging and therapy guidance in this cancer type. The prolonged tumor retention furthermore indicates a therapeutic potential of αvβ6-integrin targeted radiopharmaceuticals when labeled with radionuclides such as lutetium-177, terbium-161, or actinium-225.
Authors
- Katja Steiger (ORCID: https://orcid.org/0000-0002-7269-5433)
- Johannes Notni (ORCID: https://orcid.org/0000-0002-3964-3391)
- Jan Wuestemann
- Melanie Boxberg (ORCID: https://orcid.org/0000-0001-5989-7922)
- Kateřina Bendová (ORCID: https://orcid.org/0000-0001-6681-0100)
- Barbora Neužilová (ORCID: https://orcid.org/0000-0003-0273-6671)
- Kristýna Krasulová (ORCID: https://orcid.org/0000-0002-8303-6847)
- Marián Hajdúch (ORCID: https://orcid.org/0000-0002-4834-908X)
- Moritz Jesinghaus (ORCID: https://orcid.org/0000-0002-0018-5661)
- Elisabeth Eppard (ORCID: https://orcid.org/0000-0002-4400-2070)
- Jakub Šimeček
- Falco Reissig (ORCID: https://orcid.org/0000-0002-5203-0776)
- Tanja Groll (ORCID: https://orcid.org/0000-0002-9049-9145)
- Zbyněk Nový (ORCID: https://orcid.org/0000-0002-7716-2142)
- Michael C. Kreißl (ORCID: https://orcid.org/0000-0001-5905-6015)
- Miloš Petřík (ORCID: https://orcid.org/0000-0003-1334-5916)
Institutions
- Philipps University of Marburg (DE)
- Universitätsklinikum Gießen und Marburg (DE)
- University Hospital Olomouc (CZ)
- Regional Centre of Advanced Technologies and Materials (CZ)
- University Hospital Magdeburg (DE)
- Institute of Molecular and Translational Medicine (CZ)
- Technical University of Munich (DE)
- Trimble (Germany) (DE)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1007/s00259-025-07408-7
- Citations
- 2
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 3.24
Funders
- European Commission
- Technische Universität München
- Sächsische Aufbaubank
- Univerzita Palackého v Olomouci