Molecular Detection of Gene Mutation Related to Drug Resistance in Mycobacterium leprae
The study identified mutations in the gyrA gene which is associated with ofloxacin resistance in M. leprae in Central India. While the absence of resistance to first-line anti-leprosy drugs is reassuring, the emergence of resistance to fluoroquinolones is a cause for concern. Early detection of resistant strains facilitates prompt initiation of drug therapies, reducing their spread and advancing the global leprosy eradication effort.
Authors
- Satish Gaikwad (ORCID: https://orcid.org/0000-0002-1031-5677)
- Dhandapani Sureshgopi (ORCID: https://orcid.org/0000-0001-9128-9572)
- Pushpendra Singh (ORCID: https://orcid.org/0000-0001-9453-8669)
- Vivek Chouksey
- Anand Kumar Maurya (ORCID: https://orcid.org/0000-0002-4827-919X)
- Jerene Mathews (ORCID: https://orcid.org/0000-0003-2022-2439)
- Debasis Biswas (ORCID: https://orcid.org/0000-0002-7557-3693)
- Shashank Purwar (ORCID: https://orcid.org/0000-0002-3542-2401)
- Jitendra Singh (ORCID: https://orcid.org/0000-0001-5626-6076)
- Saumya Shukla (ORCID: https://orcid.org/0000-0002-1935-3266)
- Chandrashekhar Pathe
Institutions
- National Institute for Research in Tribal Health (IN)
- All India Institute of Medical Sciences Bhopal (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- International Journal of Mycobacteriology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.4103/ijmy.ijmy_35_25
- Citations
- 2
- Primary Topic
- Leprosy Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.79