Topographical Patterning of Cell‐Repellent Interfaces for Immune‐Stealth Implantable Electronics via Multiphoton Ablation Lithography
Stable and reliable operation of implantable electronics must ensure both high-quality electrical performance and chronic biocompatibility. Here, immune-stealth implantable electronics fabricated by multiphoton ablation lithography are introduced. The cell-repellent interface, consisting of micro-grooves and nano-islands, can be created by laser-assisted topography patterning on a thin film substrate. This patterned surface demonstrates a 20-fold increase in cell-repellent effectiveness against immune cells such as macrophages and fibroblasts due to disturbance of focal adhesion. Furthermore, the cell-repellent interface can also be patterned on the sub-micron electrode layer without compromising its electrical and electrochemical performance. When the electrocardiogram (ECG) sensor applying the cell-repellent interface is implanted into a rat subcutaneous tissue, inflammation and fibrotic reactions are effectively suppressed for 6 weeks. Consequently, stable ECG readings with clear PQRST waveforms are obtained in real-time for 4 weeks, suggesting its potential to enhance chronic biocompatibility of implantable electronics.
Authors
- Joong Hoon Lee (ORCID: https://orcid.org/0000-0003-0340-3377)
- Young Min Seo (ORCID: https://orcid.org/0000-0003-2122-2617)
- Yu‐Chan Kim
- Kang‐Sik Lee
- Kyung-Woo Lee (ORCID: https://orcid.org/0000-0002-3533-7979)
- Hojeong Jeon (ORCID: https://orcid.org/0000-0002-8277-7926)
- Sungho Moon (ORCID: https://orcid.org/0000-0002-6840-6176)
- Gwan‐Jin Ko (ORCID: https://orcid.org/0000-0001-6148-7922)
- Sungkeun Han (ORCID: https://orcid.org/0000-0003-1652-3968)
- Hyunseon Seo (ORCID: https://orcid.org/0000-0003-3063-3258)
- Suk‐Won Hwang (ORCID: https://orcid.org/0000-0002-6883-201X)
- Hyewon Kim (ORCID: https://orcid.org/0000-0002-0558-0281)
- Hojun Kim (ORCID: https://orcid.org/0000-0001-7974-1044)
- Seong-Soo Kim (ORCID: https://orcid.org/0009-0006-4094-6337)
- Chan‐Hwi Eom
- Sangmin Song
Institutions
- SK Group (South Korea) (KR)
- Seoul National University (KR)
- Korea University (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- Korea Institute of Science and Technology (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1002/advs.202506482
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Korea Institute of Science and Technology
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- KU-KIST Graduate School of Converging Science and Technology