Cellular wound healing: A two-step mechanism of plasma membrane repair by annexins and calpains
In this issue, Williams et al. (https://doi.org/10.1083/jcb.202408159) reveal a two-step plasma membrane repair process upon injury: annexins first stabilize damage sites, then calcium-activated calpains cleave these patches, triggering microvesicle shedding-mirroring the clot-and-scab resolution seen in tissue-level wound healing.
Authors
- Jesper Nylandsted (ORCID: https://orcid.org/0000-0001-6474-5093)
- Sabina Elmi
Institutions
- University of Southern Denmark (DK)
- Cancer Institute (WIA) (IN)
- Danish Cancer Society (DK)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1083/jcb.202505027
- Primary Topic
- Calpain Protease Function and Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00