Rhodium-catalyzed enantioselective transfer hydrogenation of α-chloro β-ketophosphonates <i>via</i> dynamic kinetic resolution
A rhodium-catalyzed asymmetric transfer hydrogenation (ATH) of α-chloro β-ketophosphonates <i>via</i> dynamic kinetic resolution (DKR) has been developed. A wide range of syn α-chloro β-hydroxyphosphonates were efficiently synthesized with high yields and excellent enantio- and diastereoselectivities (up to 99% ee and > 99 : 1 dr) under mild reaction conditions. A gram-scale experiment was conducted successfully, which offers a straightforward approach to a key intermediate of fosfomycin.
Authors
- Gen‐Qiang Chen (ORCID: https://orcid.org/0000-0003-2276-6800)
- Xiaobing Ding (ORCID: https://orcid.org/0000-0003-1739-7684)
- Long‐Sheng Zheng
- Xumu Zhang (ORCID: https://orcid.org/0000-0001-5700-0608)
- Virginie Ratovelomanana‐Vidal (ORCID: https://orcid.org/0000-0003-1167-1195)
- Sai Ruan (ORCID: https://orcid.org/0000-0002-7300-0226)
- Cheng Wang (ORCID: https://orcid.org/0000-0002-1834-2119)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Chimie ParisTech - PSL (FR)
- Université Paris Sciences et Lettres (FR)
- Southern University of Science and Technology (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc00367a
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Basic and Applied Basic Research Foundation of Guangdong Province