Mechanism of Shi-Yang-Xiao lotion in alleviating perianal eczema based on network pharmacology and experimental validation
Our findings indicated that SYXL repaired skin barrier, suppressed inflammation, and treated PE by decreasing the generation of interleukin-1β, interleukin-6, and TNF-α, as well as inhibiting the phosphorylation of JAK2 and STAT3.
Authors
- Zheng Tang (ORCID: https://orcid.org/0000-0001-8899-0077)
- Chuyue Huang
- Lu Wang (ORCID: https://orcid.org/0000-0003-4267-6976)
- Meng Yun Duan
- Desong Kong (ORCID: https://orcid.org/0000-0002-3787-5316)
- Qingrui Liu (ORCID: https://orcid.org/0000-0001-9481-431X)
- Qiang Leng (ORCID: https://orcid.org/0000-0002-9510-1773)
- Zhimin Fan (ORCID: https://orcid.org/0000-0001-6503-869X)
- Bingwen Zhou
- Yan Tang
- Ying-jing Dong
Institutions
- Jiangsu University (CN)
- Nanjing University of Chinese Medicine (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Xuzhou Cancer Hospital (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fmolb.2025.1621398
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00