Virtual screening, molecular dynamics simulations, and in vitro analysis of Sophora flavescens-derived aloperine against Haemonchus contortus
This study provides new perspectives for exploring the natural product ALO as an anthelmintic, HC-Pgp inhibitor, and synergist molecule. Further studies evaluating <i>in vivo</i> safety and pharmacokinetic interactions are required to validate these findings.
Authors
- Liu Yang (ORCID: https://orcid.org/0000-0002-4179-8587)
- Nian Fu (ORCID: https://orcid.org/0000-0001-8616-453X)
- Wenxi Li (ORCID: https://orcid.org/0000-0001-8449-0489)
- Bintao Zhai (ORCID: https://orcid.org/0000-0002-6378-2527)
- Anben Li
- Ma Yan
- Jun Li (ORCID: https://orcid.org/0000-0002-3257-9315)
- Qi Zhou (ORCID: https://orcid.org/0000-0002-6549-9362)
Institutions
- Jilin University (CN)
- Ningxia University (CN)
- Lanzhou Institute of Husbandry and Pharmaceutical Sciences (CN)
- Tongliao Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fvets.2025.1620324
- Primary Topic
- Helminth infection and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00