Association between trans-palmitoleic acid and metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma: NHANES 1999–2018
These findings establish TPA as an independent MASLD-HCC risk factor with distinct demographic variability, potentially mediated through lipid dysregulation. While limited by observational design, this study highlights TPA's prognostic value for HCC risk stratification, especially in non-diabetic populations (OR = 257.14). Future mechanistic studies should validate TPA's oncogenic pathways and explore therapeutic targeting of trans-fatty acid metabolism to mitigate MASLD progression. The robust dose-response relationship and metabolic mediation effects position TPA as a promising candidate for incorporation into existing HCC prediction models.
Authors
- Haijun Jiang (ORCID: https://orcid.org/0000-0002-0310-6842)
- Siyu Liu (ORCID: https://orcid.org/0000-0002-7228-3041)
- Qian Li (ORCID: https://orcid.org/0000-0001-5359-8534)
- Lingjun Zhan (ORCID: https://orcid.org/0000-0002-4486-9424)
- Jun Li (ORCID: https://orcid.org/0000-0002-7236-8088)
- Shuai Zhu (ORCID: https://orcid.org/0000-0001-8786-4941)
- Qirui Li (ORCID: https://orcid.org/0000-0003-1285-7397)
- Jinlin Cheng (ORCID: https://orcid.org/0009-0003-2880-5601)
Institutions
- National Clinical Research Center for Digestive Diseases (CN)
- First Affiliated Hospital Zhejiang University (CN)
- State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fnut.2025.1606482
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundamental Research Funds for the Central Universities
- Zhejiang Province Public Welfare Technology Application Research Project