A novel, rapid, and practical prognostic model for sepsis patients based on dysregulated immune cell lactylation
Lactylation is significantly associated with increased mortality risk in sepsis. The proposed individualized prognostic model, based on dysregulated immune cell metabolism, accurately predicts early mortality and may inform optimized clinical management of septic patients.
Authors
- Qing Li (ORCID: https://orcid.org/0009-0004-1816-9071)
- Jiqian Xu
- Patrick Shi
- Xiaoling Fang
- Xuefeng Li (ORCID: https://orcid.org/0009-0004-0803-8414)
- Mei He
- Yao Lu (ORCID: https://orcid.org/0000-0002-8426-477X)
- Chang Li (ORCID: https://orcid.org/0000-0003-0311-8701)
- You Shang
- Xiaobo Yang
Institutions
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Hubei University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1625311
- Citations
- 4
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- National Natural Science Foundation of China