Changes of methylation at enhancers appear to be essential for HIV infection progression
We have shown that progression of HIV infection is associated with hypomethylation of enhancers regardless of virus subtype. This suggests that methylation changes at the enhancers may be key for infection progression. However, we also identified methylation changes indicating that, each of the virus subtypes affects host methylome in specific manner, but these findings need to be confirmed in studies that include larger number of participants.
Authors
- Miłosz Parczewski (ORCID: https://orcid.org/0000-0003-1869-1084)
- Kaja Scheibe (ORCID: https://orcid.org/0000-0001-5951-9067)
- Tomasz Kazimierz Wojdacz (ORCID: https://orcid.org/0000-0001-6003-2432)
- Dominik Strapagiel (ORCID: https://orcid.org/0000-0001-9752-4270)
- Olga Taryma‐Leśniak (ORCID: https://orcid.org/0000-0002-1161-5399)
- Marta Sobalska‐Kwapis (ORCID: https://orcid.org/0000-0003-1982-2621)
- Malwina Karasińska‐Cieślak (ORCID: https://orcid.org/0000-0002-3269-7813)
- Bogusz Aksak‐Wąs (ORCID: https://orcid.org/0000-0003-2092-3737)
- Jan Bińkowski (ORCID: https://orcid.org/0000-0003-2374-2907)
Institutions
- Pomeranian Medical University (PL)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-06-19
- DOI
- https://doi.org/10.1186/s13148-025-01910-3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pomorski Uniwersytet Medyczny W Szczecinie