Biochemical and Clinical Risk Factors of Acute Myocardial Infarction in Very Young vs Older Patients: A Comparative Analysis

Background: Acute myocardial infarction (AMI) in very young adults is increasingly reported, yet the risk profile may differ significantly from older patients.This study aimed to compare biochemical and clinical risk factors of first AMI in very young (30 years) versus older (50 years) patients in Bangladesh. Methods: This cross-sectional observational study was conducted across four tertiary care hospitals in Dhaka over 18 months (July 2022 to December 2023). A total of 160 patients diagnosed with first AMI were enrolled and divided equally into two groups based on age: Group I (30 years, n=80) and Group II (50 years, n=80).Clinical risk factors, conventional and emerging biochemical markers were assessed and statistically compared using chi-square, t-test, and Mann-Whitney U test as appropriate.Results: Male predominance was observed in both groups, with no significant difference in gender distribution (p=0.137).Group I patients had significantly higher prevalence of smoking, dyslipidemia, obesity, family history of CAD, and substance abuse (p<0.05),whereas hypertension and diabetes were more prevalent in Group II (p<0.05).Biochemically, Group I showed significantly higher levels of troponin-I, CRP, TC, TG, LDL-C, and homocysteine, along with lower .Fasting blood glucose and serum sodium were significantly higher in Group II. Conclusion:Very young patients with first AMI exhibit distinct risk factor profiles, marked by modifiable lifestyle-related and biochemical parameters.Early identification and targeted prevention strategies are essential to mitigate cardiovascular risk in this population.